The PFL 1 mixed martial arts event for the 2022 season of the Professional Fighters League was held on April 20, 2022 at the Esports Stadium Arlington in Arlington, Texas. This marked the first regular season event of the tournament and included fights in the Lightweight and Light Heavyweight divisions. The event was headlined by a lightweight clash between Clay Collard and UFC veteran Jeremy Stephens, while 2021 champion Raush Manfio faces two-time UFC veteran Don Madge in the co-main event. The remaining two fights of the main card saw defending light heavyweight champion Antônio Carlos Júnior face off against Delan Monte, while 2019 champion Natan Schulte took on Olivier Aubin-Mercier. A lightweight bout between former WEC and UFC Lightweight Champion Anthony Pettis and Bellator veteran Myles Price was scheduled for the event but the bout was later moved to PFL 3.

PFL 1 (2022) is currently not available on any services.